UPSTREAM BIO, INC. (UPB) 8-K Summary

Date: November 5, 2025

The Company filed an 8-K reporting Item 2.02 regarding the announcement of financial results and business highlights for the quarter ended September 30, 2025.

Investors must refer to Exhibit 99.1 (Furnished Press Release) for specific financial performance metrics, guidance, and operational updates for Q3 2025.

Key Investor Notes:

• Financials: Details are contained entirely in the furnished press release (Exhibit 99.1).
• SEC Status: Information furnished under Item 2.02 is not deemed “filed” f