AstraZeneca PLC: Total Voting Rights Update

This Form 6-K provides a mandatory capital structure notification pursuant to UK Disclosure and Transparency Rules.

• Reporting Date: October 31, 2025.
• Total Voting Rights: 1,550,712,906 ordinary shares of US$0.25.
• Critical Note: No shares are held in Treasury.

This total number of voting rights is used by shareholders as the denominator for determining if notification of an interest change is required under UK FCA rules.

This submission does not contain new financial performance metrics, material business events, or f