Palisade Bio, Inc. Proxy Supplement Correction

This supplement amends the October 28, 2025 Proxy Statement for the Special Meeting on December 3, 2025 (virtual format).

The filing corrects an inadvertent error regarding the share count as of the October 17, 2025 Record Date:

• Outstanding Shares: Corrected from 139.56M to 148.96M Common Stock (reflecting 9.4M pre-funded warrant exercises).
• Quorum Requirement: Increased. Now requires holders of 49,654,858 shares present/proxied.
• Capital Structure Note: Post-correction, shares issued and outstanding total